Endocrine Abstracts

Introduction: Transgender people are a diverse population affected by a variety of negative health indicators. Studies report, among other conditions, a high prevalence of mental health problems and substance abuse. However, there are still health issues that have been poorly analyzed and long-term longitudinal follow-up studies are scarce.Objective: The aim of this study is to deep into the demographic characteristics and the psychosocial profile of tra...

Introduction: The development of new pharmacological classes for type 2 diabetes (T2D) treatment with extra-glycaemic benefits has led to the update of the treatment algorithm, presenting new effective alternatives to patients’ insulinization. The present study aims to evaluate the evolution of prescription and its impact in metabolic control of patients enrolled on an educational diabetes program of a tertiary hospital.Objectives: To evaluate trend...

Background: Mitotane is the only drug approved for treatment of adrenocortical carcinoma (ACC). We have found that mitotane leads to endoplasmic reticulum stress and decreased viability in ACC cells. It is not known by which downstream mechanisms cell death is induced by mitotane.Aim: To characterize the mechanisms underlying cell death resulting from mitotane treatment in ACC cells.Methods: Lipid peroxidation in the ACC cell line ...

Objectives: 1. To evaluate the effect after two years of bariatric surgery on comorbidities in patients with diabetes mellitus type 2 (DMT2) and obesity grade II or higher.2. Analyze the surgical complications in these patients.Material and methods: Cohort study with intrasubject measures (before-after) in patients with grade II or higher obesity and T2DM, who underwent bariatric surgery (gastric bypass or vertical gastrectomy) at ...

Introduction: Gestational diabetes mellitus (GDM) is associated with an increase risk of neonatal and maternal complications. Continuous glucose monitoring (CGM) detects glycemic patterns, which could help predict the development of maternal-fetal complications.Objective: To analyze the different glycemic patterns obtained with CGM and to correlate them with the appearance of maternal-fetal complications in GDM.Methods: Women with ...

Introduction: The aging population brought new challenges in several diseases. Pituitary tumors are usually not related with elderly, although the rise in life expectancy has allowed its diagnosis in unusual age groups.Aim: To describe the pituitary tumors diagnosed in patients with age ≥ 80 yearsMethods: Retrospective observational study which included 23 patients with pituitary tumors with age ≥ 80 years observed in c...

Introduction: Graves’ ophthalmopathy (GO) is an orbital autoimmune disorder closely linked to thyroid autoimmunity, mainly Graves’ disease. After an initial progressive inflammatory period (active phase), GO stabilizes and eventually subsides (inactive phase). Treatment should rely on a thorough assessment of the activity and severity of GO and its impact on the patient’s quality of life. Patients with active, mild disease generally benefit from local therapies ...

Retrospective study of patients with metastatic/progressive pheochromocytoma (PCC) and paraganglioma (PGL) treated with (131) I MIBG in our hospital during 2015–2018 period.Methods: There are no established criteria for establishing PCC/PGL as malignant apart from de presence of metastases at diagnosis. Radionuclide therapy (131) I-metaiodobenzylguanidine (MIBG) is frequently used in this patients when surgery is not possible. Indication of MIBG tre...

Woman, 40 years old. Smoker and habitual drinker, history of toxic consumption, anxiety-depressive syndrome, postsurgical hypothyroidism after total thyroidectomy for multinodular goiter in substitution treatment. Diabetes mellitus type 1 diagnosed in 2001 as a result of pregnancy, unstable, with poor chronic glycemic control, requiring frequent admissions to our hospitalization plant due to episodes of ketoacidosis. It requires high insulin requirements and does not present m...

Evaluation of bone quality represents a challenge since the analysis by bone mineral density (BMD), provides useful but incomplete information. New tools are arising, and amog them, TBS is emerging as a new surrogate marker of bone texture and microarchitecture which may be useful to potentially evaluate the risk of bone fracture and can be obtained from already existing BMD scans. Retrospective study of 23 patients with PHH. Clinical, analytical and BMD data were collected fo...